Effects of chemotherapeutic agent bendamustine for non-hodgkin lymphoma on spermatogenesis in mice
Minbo Zang
Qiao Zhou
Yunfei Zhu
Mingxi Liu
Zuomin Zhou
摘要：Non-Hodgkin lymphoma (NHL) is one of the most common cancers affecting men of reproductive age.The high response rate ofbendamustine as first-line treatment for NHL,coupled with young age of patients,makes elucidation of the impact of treatment on male reproduction important.Our aim was to determine the effects of bendamustine on male reproduction by animal model.Male mice were treated with bendamustine (40 mg/kg) through tail vein injection while cisplatin was given as a standard (3 mg/kg) through intraperitoneal injection.After 3 weeks,bendamustine induced weight loss and sperm morphology abnormalities were compared to the control.Additionally,sperm with folded tails were the most frequent abnormality in bendamustine-treated mice.But the mechanism of sperm abnormality induced by bendamustine remains to be elucidated.These results indicate bendamustine may affect spermatozoa of patients who have been treated for NHL.
机标关键词：
分类号：R733(造血器及淋巴系肿瘤)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 442-453 )
英文信息