Melatonin and/or rowatinex attenuate streptozotocin-induced diabetic renal injury in rats
Tarek K Motawi
Samia A Ahmed
Manal A Hamed
Shohda A El-Maraghy
Wessam M Aziz
摘要：The study aimed to explore the prophylactic effect of melatonin,rowatinex;a naturally occurring renal drug,and its combination on diabetic nephropathy in type 2 diabetic rats.Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin (50 mg/g body weight).Three days before diabetes induction,rats were daily treated with melatonin,rowatinex and their combination continuously for 8 weeks.Evaluation was done through measuring blood urea nitrogen (BUN),serum uric acid,serum creatinine,urine creatinine,creatinine clearance,nitric oxide (NO),malondialdehyde (MDA),superoxide dismutase (SOD),glutathione (GSH),total antioxidant capacity (TAC),kidney injury molecule-1 (KIM-1),heat shock protein-70 (HSP-70),caspase-3,transforming growth factor β1 (TGFβ1),DNA degradation by the comet assay and total protein contents.Histopathologic study was also done for the kidney and the pancreas.Drastic changes in all measured parameters of the diabetic rats were observed.Treatment with melatonin and rowatinex showed amelioration to variable degrees.In conclusion,melatonin showed the most potent effect on protecting rats from deleterious action of diabetic nephropathy followed by its combination with rowatinex.
机标关键词：
分类号：R246.1(中医临床学)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 113-121 )
英文信息