Emerging pathways of communication between the heart and non-cardiac organs
Eugenio Hardy-Rando
Carlos Fernandez-Patron
摘要：The breakthrough discovery of cardiac natriuretic peptides provided the first direct demonstration of the connection between the heart and the kidneys for the maintenance of sodium and volume homeostasis in health and disease.Yet,little is still known about how the heart and other organs cross-talk.Here,we review three physiological mechanisms of communication linking the heart to other organs through:i) cardiac natriuretic peptides,ii) the microRNA-208a/mediator complex subunit-13 axis and iii) the matrix metalloproteinase-2 (MMP-2)/C-C motif chemokine ligand-7/cardiac secreted phospholipase A2 (sPLA2) axis-a pathway which likely applies to the many cytokines,which are cleaved and regulated by MMP-2.We also suggest experimental strategies to answer still open questions on the latter pathway.In short,we review evidence showing how the cardiac secretome influences the metabolic and inflammatory status of non-cardiac organs as well as the heart.
机标关键词：
分类号：R393(医学分子生物学)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 145-155 )
英文信息