A meta-analysis of caspase-8-652 6N del polymorphism and digestive tract cancer risk
Haina Du
Guoxin Song
Mingzhi Fang
Yongqian Shu
Xin Zhao
Lingjun Zhu
摘要：Caspase-8 (CASP8) is one key regulator of apoptosis ofT lymphocytes and is encoded by the CASP8 gene.It has been reported that the six-nucleotide deletion polymorphism (-652 6N del) of the CASP8 gene had effect on some cancer risk.Few studies explored the association between CASP8 gene polymorphism and digestive tract cancer risk.To evaluate the association between the CASP8-652 6N del polymorphism and the risk of digestive tract cancer,we conducted this meta-analysis.We found that CASP8-652 6N del polymorphism was associated with a significantly reduced risk of digestive tract cancer in the co-dominant model (del/del vs.ins/ins:OR =0.82,95％CI =0.72-0.95;del/ins vs.ins/ins:OR =0.92,95％CI =0.87-0.97;dominant model (del/ins + del/del vs.ins/ins:OR =0.91,95％CI =0.87-0.96,recessive model:del/del vs.del/ins + ins/ins:OR =0.85,95％CI =0.75-0.97).In the stratified analysis by cancer types,we found that all genetic models had protective effect on gastric cancer.Similar results were observed for colorectal cancer under heterozygote comparison and dominant model,but not under homozygote comparison or recessive model.In addition,a significantly decreased risk was found on esophageal cancer for most genetic models,except heterozygote comparison.When stratified by ethnicity and source of control,an evidently decreased risk was identified in the Asian populations and population-based studies.In conclusion,there exists an association between the CASP8-652 6N del polymorphism and reduced digestive cancer risk,especially among Asians and population-based studies.
机标关键词：
分类号：R735.1-3(消化系肿瘤)
资助基金：81472634)((NSFC)Health Department guidance project of Jiangsu Province(Z201201)the Program for Development of Innovative Research Team in the First Affiliated Hospital of NJMU and the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(JX10231801)the Summit of the Six Top Talents Program of Jiangsu Province(2013-WSN-034)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 173-180 )
英文信息