Association of long non-coding RNA HOTAIR and MALAT1 variants with cervical cancer risk in Han Chinese women
Meiqun Jia
Lulu Ren
Lingmin Hu
Hongxia Ma
Guangfu Jin
Dake Li
Ni Li
Zhibin Hu
Dong Hang
摘要：Long noncoding RNA (lncRNA) HOTAIR and MALAT1 are implicated in the development of multiple cancers.Genetic variants within HOTAIR and MALAT1 may affect the gene expression,thereby modifying genetic susceptibility to cervical cancer.A case-control study was designed,including 1 486 cervical cancer patients and 1 536 healthy controls.Based on RegulomeDB database,11 SNPs were selected and genotyped by using Sequenom's Mass ARRAY.Univariate and multivariate logistic regression models were used to calculate the odds ratio (OR) and 95％ confidence interval (CI).We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer,while the C allele of rs 1787666 in MALAT 1 was associated with decreased risk.Compared to individuals with 0-1 unfavorable allele,those with 3-4 unfavorable alleles showed 18％ increased odds of having cervical cancer.Our findings suggest that HOTAIR rs35643724 and MALAT1 rs 1787666 might represent potential biomarkers for cervical cancer susceptibility.
机标关键词：
分类号：R737.33(泌尿生殖器肿瘤)
资助基金：This study was supported by National Natural Science Foundation of China(81502873)the Natural Science Foundation of Jiangsu Province(BK20150997)Innovation Fund of State key Laboratory of Reproductive Medicine(SKLRM-GC201802)Clinical Medicine Research Fund of the Chinese Medical Association(17020420711)Top-notch Academic Programs Project of Jiangsu Higher Education Institutions(PPZY2015A067)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 308-316 )
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