Significance of bilayer-forming phospholipids for skeletal muscle insulin sensitivity and mitochondrial function
Sophie Grapentine
Marica Bakovic
1.Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G2W1, Canada2.Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G2W1, Canada
摘要：Phosphatidylcholine (PC) and phosphatidylethanolamine (PE),which make up the bulk of mammalian cell membrane phospholipids,are recognized for their importance in metabolic health.Perturbations in the ratio of PC∶PE can affect membrane integrity and function,which thus have serious health consequences.Imbalance in the hepatic PC and PE membrane content can be linked to metabolic disturbances such as ER stress,fatty liver and insulin resistance.Given that impaired insulin sensitivity underlies the pathology of many metabolic disorders and skeletal muscle is a significant regulator of energy metabolism,it is likely that aberrant phospholipid metabolism in skeletal muscle affects whole-body insulin sensitivity.Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) activity and mitochondrial function respond to alterations in PC∶PE ratio and are associated with glucose homeostasis.Moreover,PC and PE content within the mitochondrial membrane influence mitochondrial respiration and biogenesis and thus,metabolic function.As skeletal muscle phospholipids respond to stimuli such as diet and exercise,understanding the implications of imbalances in PC∶PE ratio is of great importance in the face of the rising epidemic of obesity related diseases.This review will summarize the current state of knowledge signifying the links between skeletal muscle PC∶PE ratio and insulin sensitivity with respects to PC and PE metabolism,SERCA activity,mitochondrial function and exercise.
机标关键词：
分类号：Q545(脂类)
资助基金：This study was supported by the Canadian Institutes of Health Research grant (CIHR-ECD-144626 Ref # 46309)
论文发表日期：2020-01-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 1-13 )
英文信息