Contribution of neutrophils in the pathogenesis of rheumatoid arthritis
Lingshu Zhang1
Yi Yuan2
Qiang Xu1
Zhengyu Jiang2
Cong-Qiu Chu1
1.Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR 97239, USA;Rheumatology Section, VA Portland Healthcare System, Portland, OR 97239, USA2.Department of Rheumatology and Immunology, the First Hospital of Jilin University, Changchun, Jilin 130021, China
摘要：Neutrophils are major innate immune effector cells for host defense and have been a topic of active research for their participation in the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis (RA)due to recently discovered neutrophil extracellular trap (NET) formation.NET formation and other mechanisms leading to the release of neutrophil nuclear and cytoplasmic contents are implicated as a source of citrullinated antigens in RA.Further investigations are required to delineate what factors diverge neutrophils from host defense to autoimmune response in RA.
机标关键词：
分类号：R593.22(全身性疾病)
论文发表日期：2020-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 86-93 )
英文信息