H2S protects against diabetes-accelerated atherosclerosis by preventing the activation of NLRP3 inflammasome
Qiao Zheng
Lihong Pan
Yong Ji
1.Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China2.Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China3.Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China
摘要：Hydrogen sulfide (H2S) is an important messenger for its strong anti-inflammatory effects,which may be involved in multiple cardiovascular diseases.In our previous study,we revealed that H2S attenuated diabetes-accelerated atherosclerosis through suppressing oxidative stress.Here we report that GYY4137,a H2S donor,reduced the plaque formation of aortic roots and the levels of both intercellular cell adhesion molecule 1 (ICAM1)and vascular cell adhesion molecule 1 (VCAM1) in diabetes-accelerated atherosclerotic cells and mouse models.The inflammatory factors of TNF-α,IL-1β,IL-6,and MCP1 were also significantly reduced by GYY4137.Mechanically,GYY4137 suppressed the activation of pyrin domain containing protein 3 (NLRP3) inflammasome in diabetes-accelerated atherosclerosis conditions.Upon knockdown of NLRP3,the increase of ICAM1 and VCAM1 caused by high glucose and oxLDL could be reversed,indicating that H2S protected the endothelium by inhibiting the activity of NLRP3 inflammasome.In conclusion,our study indicates that GYY4137 effectively protects against the development of diabetes-accelerated atherosclerosis by inhibiting inflammasome activation.
机标关键词：
分类号：R543(心脏、血管（循环系）疾病)
资助基金：This work was supported by grant from National Nature Science Foundation of China (Grant No.81820108002)
论文发表日期：2020-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 94-102 )
英文信息