RNA-seq analysis identified hormone-related genes associated with prognosis of triple negative breast cancer
Fei Chen1
Yuancheng Li2
Na Qin2
Fengliang Wang3
Jiangbo Du2
Cheng Wang4
Fangzhi Du5
Tao Jiang2
Yue Jiang2
Juncheng Dai2
Zhibin Hu2
Cheng Lu3
Hongbing Shen2
1.Department of Breast Surgery, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210004, China;Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211116, China; 3Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for C2.Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211116, China;Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu 211116, China3.Department of Breast Surgery, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210004, China4.Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211116, China;Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu 211116, China; 4Department of Bioinformatics, School of Biomedical Engineering and Informatics, Nanj5.Department of Clinical Management, National Center for STD Control, Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, Jiangsu 210042, China
摘要：Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that currently lacks effective biomarkers and therapeutic targets required to investigate the diagnosis and treatment of TNBC.Here we performed a comprehensive differential analysis of 165 TNBC samples by integrating RNA-seq data of breast tumor tissues and adjacent normal tissues from both our cohort and The Cancer Genome Atlas (TCGA).Pathway enrichment analysis was conducted to evaluate the biological function of TNBC-specific expressed genes.Further multivariate Cox proportional hazard regression was performed to evaluate the effect of these genes on TNBC prognosis.In this report,we identified a total of 148 TNBC-specific expressed genes that were primarily enriched in mammary gland morphogenesis and hormone levels related pathways,suggesting that mammary gland morphogenesis might play a unique role in TNBC patients differing from other breast cancer types.Further survival analysis revealed that nine genes (FSIP1,ADCY5,FSD1,HMSD,CMTM5,AFF3,CYP2A7,ATP1A2,and Cllorf86) were significantly associated with the prognosis of TNBC patients,while three of them (ADCY5,CYP2A 7,and A TP1A2) were involved in the hormone-related pathways.These findings indicated the vital role of the hormone-related genes in TNBC tumorigenesis and may provide some independent prognostic markers as well as novel therapeutic targets for TNBC.
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分类号：R737.9(泌尿生殖器肿瘤)
论文发表日期：2020-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 129-138 )
英文信息