Severer nodular lesion in white matter than in gray matter in simian immunodeficiency virus-infected monkey, but not closely correlated with viral infection
Jingdong Zhang1
Howard Fox2
Huangui Xiong2
1.Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA2.Department of Pharmacology and Experiment Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
摘要：Immune cell accumulation and white matter anomaly are common features of HIV (human immunodeficiency virus)-infected patients in combination antiretroviral therapy (cART) era.Neuroimaging tests on cART treated patients displayed prominent diffuse white matter lesions.Notably,immune cell nodular lesion (NL) was a conspicuous type of pathological change in HIV/SIV (simian immunodeficiency virus) infected brain before cART.Therefore,we used SIV infected brain to investigate the distribution of those NLs in gray and white matters.We found a significant higher number of NLs in white matter than that in gray matter.However,virus infection correlated with macrophage NLs but not with microglia NLs,especially in white matter.In addition,NLs interrupted white matter integrity more severely,since even tiny nodules could disconnect nerve fibers in white matter tracts.In the gray matter with dense myelinated axons,NLs obviously encroached those fibers;in the area of few myelinated axons,small nodules well co-localized with extracellular matrix between neurons.
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分类号：R512.91(传染病)
论文发表日期：2020-07-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 292-300 )
英文信息