Valproic acid therapy decreases serum 25-hydroxyvitamin D level in female infants and toddlers with epilepsy-a pilot longitudinal study
Jinchun Qiu1
Hongli Guo1
Ling Li2
Zeyue Xu2
Zejun Xu1
Xia Jing1
Yahui Hu1
Xiaoyi Wen1
Feng Chen1
Xiaopeng Lu3
1.Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China2.Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China;School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China3.Department of Neurology, Children's Hospital of Nanjing Medical University, Naning, Jiangsu 210008, China
摘要：To evaluate if valproic acid (VPA) therapy is associated with vitamin D deficiency among infants and toddlers with epilepsy,a cross-sectional clinical study was conducted in 25 children with epilepsy taking VPA.Blood levels of calcium,phosphorus,alkaline phosphatase,and 25-hydroxy vitamin D [25(OH)D] and plasma VPA level were measured at 1- to 3-month intervals.At the initial and final measurements,vitamin D deficiency or insufficiency was recognized in 8 (32％) and 12 (42％),respectively.In girls,a decreasing trend in serum 25(OH)D levels (P＜0.05) was observed.Polytherapy had a significant negative effect on the longitudinal change of 25(OH)D (P＜0.05) in girls.In conclusion,our study indicates that a high proportion of girls after VPA therapy had hypovitaminosis D.
机标关键词：
分类号：R742.1(神经病学与精神病学)
论文发表日期：2021-01-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 61-67 )
英文信息