Insulin receptor is implicated in triple-negative breast cancer by decreasing cell mobility
Ying Yang1
Xiang Chen2
Changyan Ma1
1.Department of Medical Genetics,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Department of General Surgery,the Affiliated Yixing Hospital of Jiangsu University,Yixing,Jiangsu 214200,China
摘要：Triple-negative breast cancer(TNBC)has a poor prognosis and typically earlier onset of metastasis in comparison with other breast cancer subtypes.It has been reported that insulin receptor(INSR)is downregulated in TNBC,however,its clinical significance and functions in TNBC remain to be elucidated.In this study,we found that INSR expression was significantly downregulated in TNBC,and overexpression of INSR suppressed cell migration and invasion in TNBC.In addition,the survival rate of breast cancer patients with low INSR expression was lower than that of patients with high INSR expression.INSR expression was significantly correlated with lymph node metastasis,clinical tumor stages,ER status,PR status,and the proliferation index Ki-67 expression.In summary,our study suggests that INSR may serve as a biomarker for breast cancer prognosis and it may be a potential target for TNBC treatment.
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分类号：R737.9(泌尿生殖器肿瘤)
论文发表日期：2021-05-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 189-196 )
英文信息