Nanobody-based immunosensing methods for safeguarding public health
Jiarong Zhang1
Hui Sun2
Wei Pei1
Huijun Jiang3
Jin Chen4
1.Center for Global Health,The Key Laboratory of Modern Toxicology,Ministry of Education,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.School of Chemistry and Chemical Engineering,Southeast University,Nanjing,Jiangsu 211189,China3.School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China4.Center for Global Health,The Key Laboratory of Modern Toxicology,Ministry of Education,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Jiangsu Province Engineering Research Center of Antibody Drug,Key Laboratory of Antibody Technique of National Health Commission,Nanjing Medical University,Nanjing,Jiangsu 211166,China
摘要：Immunosensing methods are biosensing techniques based on specific recognition of an antigen-antibody immunocomplex,which have become commonly used in safeguarding public health.Taking advantage of antibody-related biotechnological advances,the utilization of an antigen-binding fragment of a heavy-chain-only antibody termed as 'nanobody'holds significant biomedical potential.Compared with the conventional full-length antibody,a single-domain nanobody retaining cognate antigen specificity possesses remarkable physicochemical stability and structural adaptability,which enables a flexible and efficient molecular design of the immunosensing strategy.This minireview aims to summarize the recent progress in immunosensing methods using nanobody targeting tumor markers,environmental pollutants,and foodborne microbes.
机标关键词：
分类号：R318.0(医用一般科学)
论文发表日期：2021-07-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 318-326 )
英文信息