Superior in vitro anticancer effect of biomimetic paclitaxel and triptolide co-delivery system in gastric cancer
Siwan Wang1
Hui Jiang1
Jia Wang1
Haisi Wu1
Ting Wu1
Mengnan Ni1
Qianqian Zhao1
You Ji1
Ziting Zhang2
Chunming Tang1
Huae Xu3
1.Department of Pharmaceutics,School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Department of Geriatric Gastroenterology,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China3.Department of Pharmaceutics,School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Jiangsu Key Laboratory of Molecular and Translational Cancer Research,Affiliated Cancer Hospital of Nanjing Medical University,Jiangsu Cancer Hospital,Jiangsu Institute of Cancer Research,Nanjing,Jiangsu 210009,China
摘要：As a well-known anticancer drug,paclitaxel (PTX),a first-line chemotherapeutic agent,remains unsatisfactory for gastric cancer therapy.It is reported that triptolide (TPL) could enhance the anti-gastric cancer effect of PTX.Considering the poor solubility of both drugs,we developed a red blood cell membrane-biomimetic nanosystem,an emerging tool in drug delivery,to co-load paclitaxel and triptolide (red blood cell membrane coated PTX and TPL co-loaded poly(lactic-co-glycolic acid)[PLGA]nanoparticles,RP(P/T)).The successful preparation was confirmed in terms of particle size,morphology,and surface markers assays.This biomimetic system could prolong circulation and escape immune surveillance.And these properties were verified by stability,in vitro drug release,and cellular uptake assays.Moreover,the MTT and colony formation assays demonstrated the superior anti-proliferation effect of the RP(P/T) to free drugs.The enhanced antitumor effects of RP(P/T) on migration and invasion were also evaluated by wound-healing and transwell assays.Overall,the bionic co-delivery nanoplatform with improved efficacy in vitro is a promising therapy for gastric cancer.
机标关键词：
分类号：R318.08(医用一般科学)
论文发表日期：2021-07-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 327-338 )
英文信息