A nomogram for predicting lymph node metastasis in superficial esophageal squamous cell carcinoma
Weifeng Zhang1
Han Chen1
Guoxin Zhang1
Guangfu Jin2
1.Department of Gastroenterology,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210000,China;The First Clinical Medical College of Nanjing Medical University,Nanjing,Jiangsu 210000,China2.Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
摘要：Superficial esophageal squamous cell carcinoma(SESCC)is defined as carcinoma with mucosal or submucosal invasion,regardless of regional lymph node metastasis(LNM).The lymph node status is not only a key factor to determine the training strategy,but also the most important prognostic factor in esophageal cancer.In this study,we establish a clinical nomogram for predicting LNM in patients with SESCC.A predictive model was established based on the training cohort composed of 711 patients who underwent esophagectomy for SESCC from December 2009 to June 2018.A prospective cohort of 203 patients from June 2018 to January 2019 was used for validation.Favorable calibration and well-fitted decision curve analysis were conducted and good discrimination was observed(concordance index[C-index],0.860;95％confidence interval[CI],0.825-0.894)through internal validation.The external validation cohort presented good discrimination(C-index,0.916;95％CI,0.860-0.971).This model may facilitate the prediction of LNM in patients with SESCCs.
机标关键词：
分类号：R735.1(消化系肿瘤)
论文发表日期：2021-09-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 361-370 )
英文信息