Protective effects on acute hypoxic-ischemic brain damage in mfat-1 transgenic mice by alleviating neuroinflammation
Xue Geng1
Meng Wang1
Yunjun Leng1
Lin Li1
Haiyuan Yang2
Yifan Dai2
Ying Wang2
1.Jiangsu Key Laboratory of Xenotransplantation,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Jiangsu Key Laboratory of Xenotransplantation,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Key Laboratory of Targeted Intervention of Cardiovascular Disease,Collaborative Innovation Center for Cardiovascular Disease Translational Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China
摘要：Acute hypoxic-ischemic brain damage (HIBD) mainly occurs in adults as a result of perioperative cardiac arrest and asphyxia.The benefits of n-3 polyunsaturated fatty acids (n-3 PUFAs) in maintaining brain growth and development are well documented.However,possible protective targets and underlying mechanisms of mfat-1 mice on HIBD require further investigation.The mfat-1 transgenic mice exhibited protective effects on HIBD,as indicated by reduced infarct range and improved neurobehavioral defects.RNA-seq analysis showed that multiple pathways and targets were involved in this process,with the anti-inflammatory pathway as the most significant.This study has shown for the first time that mfat-1 has protective effects on HIBD in mice.Activation of a G protein-coupled receptor 120 (GPR120)-related anti-inflammatory pathway may be associated with perioperative and postoperative complications,thus innovating clinical intervention strategy may potentially benefit patients with HIBD.
机标关键词：
分类号：R743(神经病学与精神病学)R541.78(心脏、血管（循环系）疾病)
论文发表日期：2021-11-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：17( 474-490 )
英文信息