Role of aberrant Sonic hedgehog signaling pathway in cancers and developmental anomalies
Trupti N.Patel1
Pavan Kumar Dhanyamraju2
1.School of Biosciences and Technology,Vellore Institute of Technology,Vellore Campus,Vellore,Tamil Nadu 632014,India2.Department of Pharmacology,Penn State University College of Medicine,Hershey,PA 17033,USA;Penn State Cancer Institute,Hershey,PA 17033,USA
摘要：Development is a sophisticated process maintained by various signal transduction pathways,including the Hedgehog(Hh)pathway.Several important functions are executed by the Hh signaling cascade such as organogenesis,tissue regeneration,and tissue homeostasis,among various others.Considering the multiple functions carried out by this pathway,any mutation causing aberrant Hh signaling may lead to myriad developmental abnormalities besides cancers.In the present review article,we explored a wide range of diseases caused by aberrant Hh signaling,including developmental defects and cancers.Finally,we concluded this mini-review with various treatment strategies for Hh-induced diseases.
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分类号：R730(一般性问题)
论文发表日期：2022-01-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1-9 )
英文信息