Palmitoylethanolamide,an endogenous fatty acid amide,and its pleiotropic health benefits:A narrative review
Debasis Basu
Healious Global METTA Clinic,Kolkata,West Bengal 700029,India
摘要：The global nutritional transition has led to the increased frequency and severity of chronic degenerative diseases worldwide,primarily driven by chronic inflammatory stress.At mealtimes,various pharmaceutical products aim to prevent such inflammatory stress,but they usually cause various systemic side effects.Therefore,the supplementation of natural and safe ingredients is a promising strategy to reduce the risk and severity of inflammatory stress-related diseases.Palmitoylethanolamide(PEA),an endocannabinoid-like mediator,has been extensively studied for its diverse actions,including anti-inflammatory,antimicrobial,immunostimulatory,neuroprotective,and pain-reducing effects,with high tolerability and safety in both animals and humans.Because of its multiple molecular targets and mechanisms of action,PEA has demonstrated therapeutic benefits in various diseases,including neurological,psychiatric,ophthalmic,metabolic,oncological,renal,hepatic,immunological,rheumatological,and gastrointestinal conditions.The current review highlights the roles and functions of PEA in various physiological and pathological conditions,further supporting its use as an important dietary agent.
机标关键词：ethanolreviewolampalmnolaacidamidebenefits
分类号：R96(药理学)
论文发表日期：2025-05-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 215-228 )
英文信息