Maternal depression during pregnancy and children's physical development
Di Pi1
Shuifang Lei1
Wenjing Chang2
Cong Liu3
Yangqian Jiang1
Yuanyan Dou3
Jinghan Wang1
Chang Wang1
Haowen Zhang4
Xin Xu1
Hong Lyu1
Bo Xu3
Xiumei Han3
Xiaoyu Liu3
Kun Zhou3
Tao Jiang5
Jiangbo Du6
Guangfu Jin6
Hongxia Ma6
Hongbing Shen6
Zhibin Hu6
Kan Ye2
Yuan Lin4
1.State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Department of Maternal,Child and Adolescent Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Department of Child Health Care,the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Gusu School,Nanjing Medical University,Suzhou,Jiangsu 215002,China3.State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China4.State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Department of Maternal,Child and Adolescent Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;State Key Laboratory of Reproductive Medicine(Suzhou Center),the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Gusu School,Nanjing Medical University,Suzhou,Jiangsu 215002,China5.State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Department of Biostatistics,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China6.State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;State Key Laboratory of Reproductive Medicine(Suzhou Center),the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Gusu School,Nanjing Medical University,Suzhou,Jiangsu 215002,China
摘要：Prenatal maternal psychological distress,particularly depression,has been increasingly recognized as a factor that influences fetal growth;however,its impact on early childhood development remains less well understood.The present study investigated the association between prenatal depression and children's growth trajectories,as well as the odds of overweight and obesity from 1 to 36 months,while also accounting for maternal anxiety and stress.We analyzed data from 4 710 mother-child dyads in the Jiangsu Birth Cohort,assessing maternal psychological distress across trimesters and categorizing participants into groups with mild,moderate,and severe depressive symptomatology.Children's weight-for-length z-scores(WLZ)were used to assess overweight/obesity prevalence,and growth patterns were identified through trajectory models.The results from the generalized estimating equations analysis showed that greater depressive symptomatology during pregnancy was associated with a 28%to 41%increase in the odds of childhood overweight/obesity across all three trimesters,compared with mild depressive symptomatology.We identified five distinct WLZ growth trajectory patterns,and found that mothers with greater depressive symptomatology were 39%-47%more likely to have children who followed a very-high-stable growth trajectory,compared with mothers with mild depressive symptomatology.These findings highlight the significant impact of prenatal depression on adverse growth patterns and childhood overweight/obesity,underscoring the need for early intervention.
机标关键词：depressiondevelopmentchildrenphysicalduringmaternalpregnancy
分类号：R714.25(产科学)
论文发表日期：2026-01-30
在线出版日期：2026-01-29（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1-10 )
英文信息