The mediating effect of blood pressure between healthy lifestyles and stroke:Results from the China Kadoorie Biobank study
Zidong Wang1
Jiaxi Zhou1
Xikang Fan2
Jian Su3
Houyue Geng1
Xun Wu2
Yujie Hua4
Hongfu Ren5
Jun Lyu6
Pei Pei7
Canqing Yu6
Dianjianyi Sun6
Yan Lu4
Jinyi Zhou3
Ran Tao3
1.School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Department of Noncommunicable Chronic Disease Control and Prevention,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing,Jiangsu 210009,China3.School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Department of Noncommunicable Chronic Disease Control and Prevention,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing,Jiangsu 210009,China4.Department of Noncommunicable Chronic Disease Control and Prevention,Suzhou City Center for Disease Control and Prevention,Suzhou,Jiangsu 215004,China5.Department of Noncommunicable Chronic Disease Control and Prevention,Wuzhong District of Suzhou City Center for Disease Control and Prevention,Suzhou,Jiangsu 215100,China6.Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China;Public Health and Epidemic Preparedness and Response Center,Peking University,Beijing 100191,China;Key Laboratory of Epidemiology of Major Diseases,Ministry of Education(Peking University),Beijing 100191,China7.Public Health and Epidemic Preparedness and Response Center,Peking University,Beijing 100191,China
摘要：While a healthy lifestyle is known to reduce the risk of stroke,the extent to which blood pressure(BP)mediates this association remains unclear.The present study aimed to quantify the mediating role of BP in the association between combined lifestyle factors and stroke incidence.Using data from 51 929 participants free of major cardiovascular diseases or cancer at baseline,we employed structural equation modeling to assess the mediating effects of systolic(SBP)and diastolic(DBP)blood pressure.During the follow-up,2 811 incident stroke cases were identified.A healthy lifestyle was significantly associated with a reduced risk of stroke,with SBP mediating 44.70%(β=-0.001 4,95%confidence interval[CI]:-0.001 6 to-0.001 2)and DBP mediating 37.81%(β=-0.001 2,95%CI:-0.001 5 to-0.000 9)of this association.The mediating effects were attenuated but remained significant for ischemic stroke(SBP:33.21%;DBP:27.24%).In conclusion,approximately two-fifths of the protective association between a healthy lifestyle and stroke may be mediated by BP.These findings suggest that BP control may serve as an important early indicator for evaluating the effectiveness of lifestyle interventions in reducing stroke risk.
机标关键词：pressurebetweenstrokebiobankstudybloodchinafrom
分类号：R544.1(心脏、血管（循环系）疾病)R743.1(神经病学与精神病学)
论文发表日期：2026-01-30
在线出版日期：2026-01-29（本平台首次上网日期，不代表文献的发表时间）
页数：9( 23-31 )
英文信息