Monocyte to HDL cholesterol ratio predicts obesity-associated cardiac dysfunction
Chunsheng Zhao1
Jinting Liu2
Jiaqi Zhao2
Chao Wang3
Hui Bai2
Qing Yang2
Jingjing Ben2
Xudong Zhu2
Xiaoyu Li2
Bin Jiang2
Kai Li4
Runfeng Sun4
Xuexing Ma5
Liansheng Wang6
Hanwen Zhang2
Qi Chen2
1.Department of Pathophysiology,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Department of Pathophysiology,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases,Nanjing Medical University,Nanjing,Jiangsu 211166,China3.Key Lab of Modern Toxicology of Ministry of Education,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China4.Donghai County People's Hospital,Donghai,Jiangsu 222300,China5.Department of Cardiology,the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou,Jiangsu 215006,China6.Department of Cardiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing Medical University,Nanjing,Jiangsu 211166,China
摘要：As the prevalence of obesity increases dramatically,obesity-associated cardiac dysfunction constitutes a considerable challenge to human health.This study aimed to identify more useful lipid/inflammatory markers to predict the risk of obesity-associated cardiac dysfunction.By retrospectively analyzing the clinical characteristics of 5 648 cardiac disease patients,we found that both the plasma level of high-density lipoprotein cholesterol(HDL-C)and the blood monocyte count were significantly associated with impairment of the left ventricular ejection fraction(LVEF).Univariate and multivariate regression analyses revealed that the monocyte to HDL-C ratio(MHR)was a more powerful predictor of the risk of LVEF decline than either HDL-C or monocyte alone.Mediation analysis further revealed a mediating effect of a high MHR on the decline in obesity-associated cardiac systolic function.Collectively,our results demonstrate a superior role of MHR in predicting the risk of an obesity-associated decline in cardiac systolic function among routine metabolic/inflammatory markers.
机标关键词：associatedcardiaccholesteroldysfunctionmonocyteobesitypredictsratio
分类号：R541.6(心脏、血管（循环系）疾病)
论文发表日期：2026-01-30
在线出版日期：2026-01-29（本平台首次上网日期，不代表文献的发表时间）
页数：13( 32-44 )
英文信息