Probiotic Akkermansia muciniphila alleviates acute kidney injury by protecting the intestinal barrier and modulating gut microbiota and metabolites
Juan Ni1
Zhan Yang2
Xuewei Sun2
Qian Cui3
Ruonan Zhang4
Han Lu5
Zihan Wu2
Jingfeng Zhu6
Huijuan Mao6
Kang Liu6
Chengliang Tang2
Chunhui Wang2
Changying Xing6
Jin Zhu7
1.Department of Nephrology,the First Affiliated Hospital of Nanjing Medical University,Jiangsu Province Hospital,Nanjing,Jiangsu 210029,China;Department of Infectious Disease Prevention and Control,Huadong Medical Institute of Biotechniques,Nanjing,Jiangsu 210002,China2.Department of Infectious Disease Prevention and Control,Huadong Medical Institute of Biotechniques,Nanjing,Jiangsu 210002,China3.Air Force Hospital of Eastern Theater,Nanjing,Jiangsu 210002,China4.School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China5.Department of General Surgery,The Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210011,China6.Department of Nephrology,the First Affiliated Hospital of Nanjing Medical University,Jiangsu Province Hospital,Nanjing,Jiangsu 210029,China7.Department of Infectious Disease Prevention and Control,Huadong Medical Institute of Biotechniques,Nanjing,Jiangsu 210002,China;School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China
摘要：Acute kidney injury(AKI)is a critical condition with limited effective therapies.Akkermansia muciniphila(A.muciniphila)is a probiotic with multiple beneficial effects,including the regulation of epithelial cell tight junctions.Since renal pathophysiology is associated with gut barrier integrity,we hypothesized that A.muciniphila may have preventive effects on AKI.We established a lipopolysaccharide(LPS)-induced AKI mouse model to evaluate the effects of A.muciniphila.Our findings showed that pretreatment with A.muciniphila significantly attenuated kidney injury,as evidenced by reduced serum creatinine and urea nitrogen levels,alongside decreased tubular necrosis and apoptosis.A.muciniphila preserved intestinal barrier integrity and induced marked shifts in gut microbial ecology and the metabolome.A.muciniphila notably induced an increase in the relative abundance of the phylum Proteobacteria while decreasing in that of the phylum Bacteroidetes.At the genus level,Prevotella,Faecalibaculum,Moraxella,and Lactobacillus were more abundant in A.muciniphila-pretreated mice.Metabolomic analysis revealed that A.muciniphila altered the gut metabolome,with changes involving pathways such as tyrosine metabolism,alanine/aspartate/glutamate homeostasis,cancer-related carbon flux,and GABAergic synaptic signaling.In conclusion,our findings indicate that A.muciniphila exerts renoprotective effects by modulating the gut-kidney axis,thereby establishing a foundation for future studies to explore the connection between gut microbiota and AKI.
机标关键词：akkermansiabarrierkidneyacutealleviatesinjuryintestinalmetabolites
分类号：R692(泌尿科学（泌尿生殖系疾病）)
论文发表日期：2026-01-30
在线出版日期：2026-01-29（本平台首次上网日期，不代表文献的发表时间）
页数：13( 76-88 )
英文信息