Association between psoriasis and colorectal cancer:A meta-analysis
Yufei Wang
Jiliang Lu
Ziyue Diao
Zhiqiang Yin
Department of Dermatology,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China
摘要：Dear Editor,
Psoriasis is increasingly recognized as a systemic inflammatory disease associated with several comorbidities,including metabolic syndrome,depression,and malignancies[1]. Colorectal cancer(CRC) is the third most common cancer worldwide and ranks second in mortality among all malignancies.Currently,it has become one of the most severe challenges faced by healthcare systems in many countries[2]. A previous study has found that patients with psoriasis have a significantly increased risk of developing CRC[3];however,the stratified characteristics between them are unclear. We performed a meta-analysis of observational studies examining the relationship between psoriasis and CRC. An Embase and Medline search was conducted on January 19,2025,which identified 377 relevant studies. The search strategy and PRISMA study flow chart are presented in Supplementary Table 1 and Supplementary Fig. 1. Following screening,a total of 10 relevant articles were selected for inclusion. We extracted study design,first author's last name,publication year,population information,and risk estimates (i.e.,hazard ratio[HR],incidence rate ratio[IRR],risk ratio[RR],and odds ratio[OR]) with 95％confidence intervals (CIs) for the association between psoriasis and CRC (Supplementary Table 2). The Newcastle-Ottawa Scale was used to assess the risk of bias in the included studies (Supplementary Fig. 2).Data analysis was conducted using RevMan 5.4. The inverse-variance weighting method,random-effects model,and I2 statistics for heterogeneity were used for analysis (Supplementary Fig. 3).
机标关键词：meta-analysisassociationbetweencancercolorectalpsoriasis
分类号：R758.63(皮肤病学与性病学)
论文发表日期：2026-01-30
在线出版日期：2026-01-29（本平台首次上网日期，不代表文献的发表时间）
页数：4( 93-96 )