Hepatitis C virus point-of-care microelimination approach in a vulnerable population in the South of Spain
José María Pinazo-Bandera1
Jesús Aranda2
Alberto Manuel García-García2
Ramiro Alcántara2
Aida Ortega-Alonso1
Enrique Del Campo-Herrera2
Encarnación Clavijo3
M.Dolores García-Escaño2
Juan Jesús Ruiz Ruiz4
Mónica Morales-Herrera5
Vanesa Valle-López5
Rosa Martín-Alarcón6
Isabel Viciana3
Juan Bautista Jiménez4
Felix Fernández-García2
Juan Pedro Toro-Ortiz2
Elena Sánchez-Yáñez7
Ismael Álvarez-Álvarez1
Raúl J.Andrade1
Mercedes Robles-Díaz1
Miren García-Cortés1
1.Gastroenterology Department,Málaga Biomedicine Research Institute-IBIMA BIONAND Platform,Virgen de la Victoria University Hospital,University of Málaga,Málaga,Spain;Biomedic Research Network in Hepatic and Digestive Diseases(CIBERehd),Madrid,Spain2.Gastroenterology Department,Málaga Biomedicine Research Institute-IBIMA BIONAND Platform,Virgen de la Victoria University Hospital,University of Málaga,Málaga,Spain3.Microbiology Department,Málaga Biomedicine Research Institute-IBIMA BIONAND Platform,Virgen de la Victoria University Hospital,University of Málaga,Málaga,Spain4.Provincial Center for Drug Addiction,Provincial Council of Málaga,Málaga,Spain5.Meeting and Reception Center,(CEA-Cruz Roja),Málaga,Spain6.Municipal Reception Center,Málaga,Spain7.Farmacy Department,Virgen de la Victoria University Hospital,Málaga,Spain
摘要：Background:Since the introduction of direct-acting antivirals,thousands of chronic hepatitis C patients have been successfully treated.However,vulnerable populations have a higher prevalence of hepatitis C virus(HCV)infection and face barriers that impede their access to antivirals.We carried out an HCV microelimination program focused on vulnerable population groups in Malaga.
Methods:People in drug addiction treatment centers and homeless shelters in Malaga who participated in the program between October 2020 and October 2021 were included.After providing participants with educational information on HCV,a dry drop test(DDT)was used to collect blood for subsequent screening for HCV infection.The participants who were diagnosed with HCV infection were scheduled for comprehensive healthcare assessments,including blood tests,ultrasonography,elastography,and the prescription of antivirals,all conducted in a single hospital visit.Sustained viral response(SVR)was analysed 12 weeks after end of treatment.
Results:Of the 417 persons invited to participate,271(65％)agreed to participate in the program.These participants were screened for HCV infection and 28 of them were diagnosed with HCV infection(10％).These hepatitis C-infected patients had a mean age of 53±9 years;86％were males and 93％were or had been drug users.Among 23 patients with HCV infection,HCV genotype 1a predomi-nated(74％).Medical exams showed that 19％(4/21)had advanced fibrosis(F3-4),and 5％(1/21)had portal hypertension.Finally,23 infected patients received treatment with glecaprevir/pibrentasvir or sofosbuvir/velpatasvir and SVR was confirmed in 22 patients(96％).
Conclusions:Drug users and homeless people have a higher prevalence of HCV infection than the general population.The microeli-mination program with educational activity and screening tools achieved a high participation rate,easy healthcare access,and a high rate of SVR despite the SARS-CoV-2 pandemic.
机标关键词：populationmicrovirusapproacheliminationhepatitispoint-of-caresouth
论文发表日期：2024-02-28
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：6( 47-52 )
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