Comparison of clinical efficacy between LAPS and ALPPS in the treatment of hepatitis B virus-related hepatocellular carcinoma
Zebin Chen1
Shunli Shen1
Wenxuan Xie1
Junbin Liao1
Shiting Feng2
Shaoqiang Li1
Jiehui Tan3
Ming Kuang1
1.Centre of Hepato-Pancreato-Biliary Surgery,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,P.R.China2.Department of Diagnostic Radiology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,P.R.China3.Department of Hepatobiliary Surgery,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,P.R.China
摘要：Background:Insufficient post-operative future liver remnant(FLR)limits the feasibility of hepatectomy for patients.Staged hepatectomy is an effective surgical approach that can improve the resection rate of hepatocellular carcinoma(HCC).This study aimed to compare the safety and efficacy of laparoscopic microwave ablation and portal vein ligation for staged hepatectomy(LAPS)and classical associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in the treatment of hepatitis B virus(HBV)-related HCC.
Methods:Clinical data of patients with HBV-related HCC who underwent LAPS or ALPPS in our institute between January 2017 and May 2022 were retrospectively analysed.
Results:A total of 18 patients with HBV-related HCC were retrospectively analysed and divided into the LAPS group(n=9)and ALPPS group(n=9).Eight patients in the LAPS group and eight patients in the ALPPS group proceeded to a similar resection rate(88.9％vs 88.9％,P=1.000).The patients undergoing LAPS had a lower total comprehensive complication index than those undergoing ALPPS but there was not a significant different between the two groups(8.66 vs 35.87,P=0.054).The hypertrophy rate of FLR induced by ALPPS tended to be more rapid than that induced by LAPS(24.29 vs 13.17 mL/d,P=0.095).The 2-year recurrence-free survival(RFS)was 0％for ALPPS and 35.7％for LAPS(P=0.009),whereas the 2-year overall survival for ALPPS and LAPS was 33.3％and 100.0％(P=0.052),respectively.
Conclusions:LAPS tended to induce lower morbidity and FLR hypertrophy more slowly than ALPPS,with a comparable resection rate and better long-term RFS in HBV-related HCC patients.
机标关键词：alppsclinicalbetweenlapscarcinomacomparisonefficacyhepatitis
论文发表日期：2024-02-28
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：9( 53-61 )
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