Association between adjuvant chemotherapy and survival in stageⅠ gastric cancer patients after curative resection
Qiuying Chen1
Hua Xiao2
Lu Zhang1
Jingjing You1
Zhe Jin1
Bin Zhang1
1.Department of Radiology,The First Affiliated Hospital,Jinan University,Guangzhou,Guangdong,P.R.China;Graduate College,Jinan University,Guangzhou,Guangdong,P.R.China2.Department of Hepatobiliary and Intestinal Surgery,Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha,Hunan,P.R.China
摘要：Background:The efficacy of adjuvant chemotherapy(AC)on survival outcomes of patients with stage Ⅰ gastric cancer(GC)after curative resection remains controversial.We aimed to determine whether these patients would benefit from AC.
Methods:This retrospective study included patients with pathologically confirmed stage Ⅰ GC who underwent curative resection between November 2010 and December 2020.Patients were divided into AC and non-AC groups,then a 1∶1 propensity score matching(PSM)analysis was performed to minimize the selection bias.Potential risk factors including age,pN stage,pT stage,lymphovascular invasion,perineural invasion,tumor size,histological type,and carcinoembryonic antigen level were used as matching covariates.The recurrence-free survival(RFS)and disease-specific survival(DSS)were compared between groups using the Kaplan-Meier method.
Results:A total of 902 consecutive patients were enrolled and 174(19.3％)patients were treated with AC.PSM created 123 pairs of patients.Before PSM,patients receiving AC had lower 10-year RFS rates(90％ vs 94.6％,P=0.035)than those who did not receive AC;the two groups had similar 10-year DSS rates(93.8％ vs 95.0％,P=0.240).After PSM,there were no statistical differences in the 10-year RFS(90.9％ vs 93.0％,P=0.507)or DSS rates(93.5％ vs 93.6％,P=0.811)between the two groups.Similar results were found in the stage ⅠA and ⅠB subgroups.Moreover,these findings were not affected by AC cycles.
Conclusions:The addition of AC could not provide survival benefits for patients with stage Ⅰ GC after surgery and follow-up is thus recommended.However,large-scale randomized clinical trials are required.
机标关键词：associationbetweenstagecancerafteradjuvantchemotherapycurative
论文发表日期：2024-02-28
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：7( 62-68 )
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