Predicted pro-inflammatory hs-CRP score and non-alcoholic fatty liver disease
Akinkunmi Paul Okekunle1
Jiyoung Youn2
Sihan Song2
Goh Eun Chung3
Sun Young Yang3
Young Sun Kim3
Jung Eun Lee4
1.Department of Food and Nutrition,College of Human Ecology,Seoul National University,Seoul,Korea;Research Institute of Human Ecology,Seoul National University,Seoul,Korea2.Department of Food and Nutrition,College of Human Ecology,Seoul National University,Seoul,Korea3.Healthcare System Gangnam Center,Healthcare Research Institute,Seoul National University Hospital,Seoul,Korea4.Department of Food and Nutrition,College of Human Ecology,Seoul National University,Seoul,Korea;Healthcare System Gangnam Center,Healthcare Research Institute,Seoul National University Hospital,Seoul,Korea
摘要：Background:Non-alcoholic fatty liver disease(NAFLD)is a major contributor to liver diseases globally,yet there are limited studies investigating the impact of diet and lifestyle factors on its development.This study aimed to examine the association between the prevalence of NAFLD and predicted pro-inflammatory high-sensitivity C-reactive protein(hs-CRP)score.
Methods:We included 1,076 Korean adults who underwent a medical examination at the Seoul National University Hospital Gangnam Healthcare Center in Korea between May and December 2011 and updated in 2021.The predicted pro-inflammatory hs-CRP score was derived from pro-inflammatory demographic,lifestyle,dietary,and anthropometric factors,and NAFLD was diagnosed using liver ultrasound.Multivariable-adjusted odds ratios(ORs)and 95％confidence intervals(CIs)of NAFLD odds accord-ing to predicted pro-inflammatory hs-CRP score were estimated using logistic regression at a two-sided P＜0.05.
Results:Among the 1,076 participants,320 had NAFLD.The multivariable-adjusted ORs and 95％CIs for NAFLD by tertiles of predicted pro-inflammatory hs-CRP score were 1.00,3.30(2.06,5.30),18.25(10.47,31.81;P＜0.0001)in men and women combined,1.00,1.77(1.10,2.84),and 3.26(2.02,5.28;P＜0.0001)among men only,and 1.00,3.03(1.39,6.62),and 16.71(7.05,39.63;P＜0.0001)among women only.
Conclusions:Predicted pro-inflammatory hs-CRP score was associated with higher odds of NAFLD.Adopting dietary and lifestyle changes related to lower inflammation might be a valuable strategy for preventing NAFLD.
机标关键词：scorediseasefattyinflammatorylivernon-alcoholicpredicted
论文发表日期：2024-02-28
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：7( 69-75 )
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