Identification and genetic counseling for a novel variant of MLH1 associated with lynch syndrome in colorectal cancer:a case report
Xiaohuan Lu1
Hongyan Zhang2
Luming Xu2
Yang Cao1
Yuan Li1
Wei Li1
Gang Li1
Feng Xue3
Zheng Wang1
1.Department of Gastrointestinal Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,P.R.China2.Department of Clinical Laboratory,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,P.R.China3.Department of General Surgery,Affiliated Hospital of Yangzhou University,Yangzhou,Jiangsu,P.R.China
摘要：Introduction
Lynch syndrome(LS)is an autosomal dominant condition caused by pathogenic variants in mismatch repair(MMR)genes.LS is as-sociated with an 80％lifetime risk for colorectal cancer(CRC);it is also characterized by extracolonic tumors,including endome-trial,stomach,or ovarian cancer[1,2].
机标关键词：identificationgeneticreportvariantcancercasenovelwith
论文发表日期：2024-02-28
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：3( 94-96 )