DOI: 10.1515/mr-2021-0035
Evolutionary dynamics of the severe acute respiratory syndrome coronavirus 2 genomes
Zhaohui Qian1
Pei Li2
Xiaolu Tang3
Jian Lu4
1.NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100176,China2.NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100871,China3.State Key Laboratory of Protein and Plant Gene Research,Center for Bioinformatics,School of Life Sciences,Peking University,Beijing,100176,China4.State Key Laboratory of Protein and Plant Gene Research,Center for Bioinformatics,School of Life Sciences,Peking University,Beijing,100871,China
摘要：The coronavirus disease 2019(COVID-19)pandemic has caused immense losses in human lives and the global economy and posed significant challenges for global public health.As severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of COVID-19,has evolved,thousands of single nucleotide variants(SNVs)have been identified across the viral genome.The roles of individual SNVs in the zoonotic origin,evolution,and transmission of SARS-CoV-2 have become the focus of many studies.This re-view summarizes recent comparative genomic analyses of SARS-CoV-2 and related coronaviruses(SC2r-CoVs)found in non-human animals,including delineation of SARS-CoV-2 lineages based on characteristic SNVs.We also discuss the current understanding of receptor-binding domain(RBD)evolution and characteristic mutations in variants of concern(VOCs)of SARS-CoV-2,as well as possible co-evolution be-tween RBD and its receptor,angiotensin-converting enzyme 2(ACE2).We propose that the interplay between SARS-CoV-2 and host RNA editing mechanisms might have partially resul-ted in the bias in nucleotide changes during SARS-CoV-2 evo-lution.Finally,we outline some current challenges,including difficulty in deciphering the complicated relationship between viral pathogenicity and infectivity of different variants,and monitoring transmission of SARS-CoV-2 between humans and animals as the pandemic progresses.
机标关键词：dynamicsacutecoronavirusevolutionarygenomesrespiratoryseveresyndrome
论文发表日期：2022-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：20( 3-22 )
英文信息