DOI: 10.1515/mr-2021-0028
Extracellular matrix in cancer progression and therapy
Xiuxiu He1
Byoungkoo Lee2
Yi Jiang3
1.Department of Medical Physics,Memorial Sloan-Kettering Cancer Center,New York,NY,USA2.The Jackson Laboratory for Genomic Medicine,Farmington,CT,USA3.Department of Mathematics and Statistics,Georgia State University,25 Park Place,Atlanta,GA 30303,USA
摘要：The tumor ecosystem with heterogeneous cellular compositions and the tumor microenvironment has increas-ingly become the focus of cancer research in recent years.The extracellular matrix(ECM),the major component of the tu-mor microenvironment,and its interactions with the tumor cells and stromal cells have also enjoyed tremendously increased attention.Like the other components of the tumor microenvironment,the ECM in solid tumors differs signifi-cantly from that in normal organs and tissues.We review recent studies of the complex roles the tumor ECM plays in cancer progression,from tumor initiation,growth to angio-genesis and invasion.We highlight that the biomolecular,biophysical,and mechanochemical interactions between the ECM and cells not only regulate the steps of cancer progres-sion,but also affect the efficacy of systemic cancer treatment.We further discuss the strategies to target and modify the tumor ECM to improve cancer therapy.
机标关键词：matrixcancerextracellularprogressiontherapy
论文发表日期：2022-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 125-139 )
英文信息