DOI: 10.1515/mr-2021-0021
Comprehensive narrative review of real-world COVID-19 vaccines:viewpoints and opportunities
Shelan Liu1
Min Kang2
Na Zhao3
Yali Zhuang2
Shijian Li4
Tie Song5
1.Department of Infectious Diseases,Zhejiang Provincial Centre for Disease Control and Prevention,Hangzhou,Zhejiang Province,China2.Guangdong Provincial Centre for Disease Control and Prevention,Guangzhou,Guangdong Province,China3.School of Ecology and Environment,Anhui Normal University,Wuhu,Anhui Province,China4.Department of Public Health,SUNY Old Westbury,New York,USA5.Guangdong Provincial Centre for Disease Control and Prevention,No.160 QunXian Road,Panyu District,Guangzhou,Guangdong Province 511430,China
摘要：Currently,people all over the world have been affected by coronavirus disease 2019(COVID-19).Fighting against COVID-19 is the top priority for all the countries and nations.The development of a safe and effective COVID-19 vaccine is considered the optimal way of ending the pandemic.Three hundred and 44 vaccines were in devel-opment,with 149 undergoing clinical research and 35 authorized for emergency use as to March 15 of 2022.Many studies have shown the effective role of COVID-19 vaccines in preventing SARS-CoV-2 infections as well as serious and fatal COVID-19 cases.However,tough challenges have arisen regarding COVID-19 vaccines,including long-term immu-nity,emerging COVID-19 variants,and vaccine inequalities.A systematic review was performed of recent COVID-19 vaccine studies,with a focus on vaccine type,efficacy and effectiveness,and protection against SARS-CoV-2 variants,breakthrough infections,safety,deployment and vaccine strategies used in the real-world.Ultimately,there is a need to establish a unified evaluation standard of vaccine effec-tiveness,monitor vaccine safety and effectiveness,along with the virological characteristics of SARS-CoV-2 variants;and determine the most useful booster schedule.These as-pects must be coordinated to ensure timely responses to beneficial or detrimental situations.In the future,global ef-forts should be directed toward effective and immediate vaccine allocations,improving vaccine coverage,SARS-CoV-2 new variants tracking,and vaccine booster development.
机标关键词：covid-19reviewcomprehensivenarrativeopportunitiesreal-worldvaccinesviewpoints
论文发表日期：2022-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：28( 169-196 )
英文信息