DOI: 10.1515/mr-2023-0001
Ferritin-based nanomedicine for disease treatment
Yuanjun Zhu1
Yuefeng Zhu2
Tianmiao Cao2
Xiaoyu Liu2
Xiaoyan Liu1
Yi Yan2
Yujie Shi2
Jian-Cheng Wang3
1.Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems,State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing,China;Department of Molecular and Cellular Pharmacology,School of Pharmaceutical Sciences,Peking University,Beijing,China2.Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems,State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing,China3.Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems,State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China; Laboratory of Innovative Formulations and Pharmaceutical Excipients,Ningbo Institute of Marine Medicine,Peking University,Ningbo 315832,Zhejiang Province,China
摘要：Ferritin is an endogenous protein which is self-assembled by 24 subunits into a highly uniform nanocage structure.Due to the drug-encapsulating ability in the hol-low inner cavity and abundant modification sites on the outer surface,ferritin nanocage has been demonstrated great potential to become a multi-functional nanomedicine platform.Its good biocompatibility,low toxicity and immu-nogenicity,intrinsic tumor-targeting ability,high stability,low cost and massive production,together make ferritin nanocage stand out from other nanocarriers.In this review,we summarized ferritin-based nanomedicine in field of disease diagnosis,treatment and prevention.The different types of drugs to be loaded in ferritin,as well as drug-loading methods were classified.The strategies for site-specific and non-specific functional modification of ferritin were inves-tigated,then the application of ferritin for disease imaging,drug delivery and vaccine development were discussed.Finally,the challenges restricting the clinical translation of ferritin-based nanomedicines were analyzed.
机标关键词：diseaseferritin-basednanomedicinetreatment
论文发表日期：2023-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：26( 49-74 )
英文信息