DOI: 10.1515/mr-2023-0056
The role of Down syndrome cell adhesion molecule in Down syndrome
Ty Hergenreder1
Tao Yang1
Bing Ye2
1.Life Sciences Institute and Department of Cell and Developmental Biology,University of Michigan,Ann Arbor,MI,USA2.Life Sciences Institute and Department of Cell and Developmental Biology,University of Michigan,210 Washtenaw Avenue,Room 5403,Ann Arbor,MI,48109,USA
摘要：Down syndrome(DS)is caused by the presence of an extra copy of the entire or a portion of human chromosome 21(HSA21).This genomic alteration leads to elevated expression of numerous HSA21 genes,resulting in a variety of health issues in individuals with DS.Among the genes located in the DS "critical region" of HSA21,Down syndrome cell adhesion molecule(DSCAM)plays an important role in neuronal development.There is a growing body of evidence underscoring DSCAM's involve-ment in various DS-related disorders.This review aims to provide a concise overview of the established functions of DSCAM,with a particular focus on its implications in DS.We delve into the roles that DSCAM plays in DS-associated diseases.In the concluding section of this review,we explore prospective avenues for future research to further unravel DSCAM's role in DS and opportunities for thera-peutic treatments.
机标关键词：downrolecelladhesionmoleculesyndrome
论文发表日期：2024-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 31-41 )
英文信息