DOI: 10.1515/mr-2024-0023
Biophysical stimuli for promoting bone repair and regeneration
Yunyang Bai1
Xiaochan Li1
Ke Wu1
Boon C.Heng2
Xuehui Zhang3
Xuliang Deng4
1.Department of Geriatric Dentistry,Peking University School and Hospital of Stomatology,Beijing,China2.Department of Dental Materials & Dental Medical Devices Testing Center,Peking University School and Hospital of Stomatology,Beijing 100081,China3.Department of Dental Materials &Dental Medical Devices Testing Center,Peking University School and Hospital of Stomatology,Beijing 100081,China4.Department of Geriatric Dentistry,Peking University School and Hospital of Stomatology,Beijing 100081,China;Department of Dental Materials &Dental Medical Devices Testing Center,Peking University School and Hospital of Stomatology,Beijing 100081,China;National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,NMPA Key Laboratory for Dental Materials,Beijing Laboratory of Biomedical Materials & Beijing Key Laboratory of Digital Stomatology,Peking University School and Hospital of Stomatology,Beijing 100081,China
摘要：Bone injuries and diseases are associated with profound changes in the biophysical properties of living bone tissues,particularly their electrical and mechanical properties.The biophysical properties of healthy bone are attributed to the complex network of interactions between its various cell types(i.e.,osteocytes,osteoclast,immune cells and vascular endothelial cells)with the surrounding extracellular matrix(ECM)against the backdrop of a myriad of biomechanical and bioelectrical stimuli arising from daily physical activities.Understanding the pathophysiological changes in bone biophysical properties is critical to devel-oping new therapeutic strategies and novel scaffold bio-materials for orthopedic surgery and tissue engineering,as well as provides a basis for the application of various biophysical stimuli as therapeutic agents to restore the physiological microenvironment of injured/diseased bone tissue,to facilitate its repair and regeneration.These include mechanical,electrical,magnetic,thermal and ultrasound stimuli,which will be critically examined in this review.A significant advantage of utilizing such biophysi-cal stimuli to facilitate bone healing is that these may be applied non-invasively with minimal damage to sur-rounding tissues,unlike conventional orthopedic surgical procedures.Furthermore,the effects of such biophysical stimuli can be localized specifically at the bone defect site,unlike drugs or growth factors that tend to diffuse away after delivery,which may result in detrimental side effects at ectopic sites.
机标关键词：regenerationbiophysicalbonepromotingrepairstimuli
论文发表日期：2025-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：22( 1-22 )
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