压缩刺激影响关节软骨细胞代谢和力学特性的研究进展
苑伟
段王平
卫小春
1.骨与软组织损伤修复山西省重点实验室,山西医科大学第二医院骨科,0300012.骨与软组织损伤修复山西省重点实验室,山西医科大学第二医院骨科,0300013.骨与软组织损伤修复山西省重点实验室,山西医科大学第二医院骨科,030001
摘要：Articular cartilages endure a variety of dynamic stresses in a complex physiological environment. As the main force of normal human articular movement, the pressure can change the biological and mechanical properties of chondrocytes, including changes in the stress and strain of articular cartilage tissues, hydrostatic pressure, interstitial fluid flow, flow energy, osmotic pressure, changes of transferring between tissues and cell deformations and so on. Because of the specificity of the mechanical environment, the changes of the mechanical properties of chondrocytes will have an effect on the physiological functions of articular cartilages. It is difficult for articular cartilage injuries caused by many factors to repair themselves, which has brought great difficulties to the clinical treatment. There are many traditional methods of repairing cartilage defects clinically, while some shortcomings exist. Thanks to the development of tissue engineering technology, there is a new idea and method for the regeneration and repair of articular cartilage defects. Scaffold materials are mainly utilized to provide a space structure for the proliferation and matrix secretion of chondrocytes, and a kind of structure is formed similar to normal cartilage tissues to transplant and repair articular cartilage defects. Many factors get involved in the construction of tissue-engineered cartilages with good functions, such as seed cells, scaffold materials, culture conditions and so on, among which mechanical stimulation has a particularly important effect on the metabolism of articular cartilage matrixes and their mechanical properties. Therefore, an intensive study of the mechanical properties of chondrocytes will further clarify a series of processes needed to maintain normal physiological functions, such as the stress conditions and responses. There will be positive signiifcance for the understanding of the biological properties of chondrocytes, the effects of compression stimulation on the mechanical properties of cells and the biological advantages as tissue-engineered cartilage seed cells.
机标关键词：软骨细胞代谢关节软骨细胞力学特性
分类号：R681.3(骨科学（运动系疾病、矫形外科学）)
资助基金：国家自然科学基金(31271033)高等学校博士学科点专项科研基金(20121417120004)山西医科大学博士启动基金(055197)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 699-702 )
英文信息