大麻素系统在骨科中的应用进展
杨豪
王建儒
郑召民
1.中山大学附属第一医院脊柱外科,广州,5100802.中山大学附属第一医院脊柱外科,广州,5100803.中山大学附属第一医院脊柱外科,广州,510080
摘要：Cannabinoids have been implicated in many physiological processes, ranging from appetite regulation and pain perception to motor function development and immune response regulation. And cannabinoids have been approved for clinical use in the treatment of the following symptoms, such as nausea and vomiting caused by cytostatic therapy, loss of appetite in HIV/Aids-related cachexia, refractory spasticity caused by multiple sclerosis, the side effects of chemotherapy in cancer patients, chronic pain and so on. Recent studies found the expressions of cannabinoids and cannabinoid receptors in the bone and synovial tissues, and their important roles in bone metabolism were conifrmed. Preclinical testing in animal models demonstrated that cannabinoids could alleviate the development of arthritis, prevent osteoporosis and improve the neurological function following spinal cord injury. So the recent progress in the application of cannabinoid system in orthopaedics was reviewed in this paper, with the expectation to provide a new direction for orthopaedic research and apply cannabinoid drugs in the clinical treatment of orthopaedic diseases.
机标关键词：大麻素系统骨科内源性cannabinoid receptors花生四烯酸spinal cord injurymultiple sclerosis
分类号：R687.4(骨科学（运动系疾病、矫形外科学）)TH776.1(仪器、仪表)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 703-706 )
英文信息