炎症细胞因子在骨性关节炎疼痛中的作用机制
姚志华
裘敏蕾
樊天佑
1.200071,上海中医药大学附属市中医医院2.200071,上海中医药大学附属市中医医院3.200071,上海中医药大学附属市中医医院
摘要：In order to provide theoretical basis for the clinical treatment of osteoarthritis, the mechanism of inflammatory cytokines in osteoarthritis pain was investigated. A computer-based search of PubMed and China National Knowledge Infrastructure ( CNKI ) database was performed for the related articles with the keywords of“inflammatory cytokines, interleukin, tumor necrosis factor, chemokines, osteoarthritis pain, neuropathic pain and biochemical mechanisms”in English or in Chinese. The literatures related to the mechanism of inlfammatory cytokines in osteoarthritis pain were selected. A total of 84 literatures were primarily selected and 42 articles were reviewed according to the inclusion criteria. Osteoarthritis pain is one of the main factors affecting the life quality of the patients, and a variety of abnormal cells of the peripheral and central nervous systems were involved. Inlfammatory cytokines played an important role in the pathogenesis of osteoarthritis. The relationship between osteoarthritis pain and common inlfammatory cytokines were reviewed in the review, so as to explore the important role of inlfammatory cytokines in osteoarthritis pain and provide theoretical basis for the clinical treatment of osteoarthritis.
机标关键词：炎症细胞因子骨性关节炎关节炎疼痛clinical treatmenttheoretical basislife quality痛觉过敏生活质量
分类号：R684.3(骨科学（运动系疾病、矫形外科学）)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 374-377 )
英文信息