骨肉瘤的靶向治疗
田大为1
蔡林2
1.442000十堰，湖北医药学院附属东风总医院骨科; 430071 武汉大学中南医院骨科2.430071,武汉大学中南医院骨科
摘要：As a kind of malignant tumor derived from mesenchymal tissues, osteosarcoma is harmful to adolescent health and may cause death, with a higher grade of malignancy and metastasis and worse treatment outcomes and prognosis. Chemotherapy, especially neoadjuvant chemotherapy, plays a very important role in the treatment of osteosarcoma. However, because of the deifciency of treatment speciifcity, the antineoplastic drug will do harm to normal cells and organs and meanwhile kill osteosarcoma cells. Depending on selective functions of the oriented part, targeted therapies will selectively act on target locations and toxic reactions will also be reduced for normal organs. Different mechanisms of targeted therapies will be used on different target points. The key examples of target identiifcation in osteosarcomas is highlighted in this review. The drug doses and side effects can be reduced and the treatment effects can be improved, with potential clinical values in the future.
机标关键词：靶向治疗骨肉瘤
分类号：R738.1(运动系肿瘤)
资助基金：中央高校基本科研业务费专项武汉大学研究生科研项目(201130302020006)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 548-550 )
英文信息