运动系统中干细胞衰老及其机制研究进展
贾治伟
李威
王德利
何勍
阮狄克
1.海军总医院, 北京,1000482.海军总医院, 北京,1000483.海军总医院, 北京,1000484.海军总医院, 北京,1000485.海军总医院, 北京,100048
摘要：Stem cells are of self-renewing ability and multi-differentiating potential, with a broad prospect in clinical application. It has been proved that stem cells can be found in almost all adult tissues and organs. A new direction has been inspired in basic and clinical studies of the treatment of musculoskeletal diseases after the discovery of stem cells in locomotor system. However, as the research on stem cell transplantation continues, stem cell aging has been gradually recognized and gaining extensive attention. It is thought that stem cell aging is an important reason for organism aging and diseases, and also a new challenge to stem cell treatment. Recently, the aging of bone-marrow mesenchymal stem cells, skeletal muscle stem cells, tendon stem cells and articular cartilage stem cells have been proved. The manifestations of stem cell aging in locomotor system mainly include the alternations of quality, quantity and migration ability. Stem cell aging is conducted through the telomere and telomerase, p19Arf / p53 / p21Cip1 / Wafl pathway, p16INK4a / Rb pathway, Wnt pathway and MicroRNA. The studies on stem cell aging in locomotor system is at the beginning stage and there are still many issues needed to be solved. The research progress on stem cell aging and its mechanism in locomotor system are reviewed in this paper.
机标关键词：运动系统细胞衰老机制研究mesenchymal stem cells干细胞移植cell agingstem cell transplantation细胞移植治疗
分类号：Q254(细胞生理学)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 770-773 )
英文信息