骨肉瘤转移侵袭机制研究进展
胡涂
杨庆诚
程冬冬
1.200023,上海交通大学附属第六人民医院骨科2.200023,上海交通大学附属第六人民医院骨科3.200023,上海交通大学附属第六人民医院骨科
摘要：Osteosarcoma ( OS ) is the most common primary malignant bone tumor in the children and adolescent, with poor prognosis as a result of early metastasis and relapse. The 5-year disease-free survival rate in the patients with localized disease has been greatly improved since the invention of preoperative and postoperative chemotherapy. However, the prognosis for the patients with metastatic OS remains poor, and the 5-year disease-free survival rate is no more than 20%. In recent years, numerous investigations about the mechanism of metastasis or invasion of OS spring up. A consensus has been reached that microRNA, lncRNA, DNA and related proteins are involved in this process. A study on the intrinsic mechanism of these factors in OS will stimulate new points of view and lead to new breakthrough directions.
关键词：骨肉瘤肿瘤转移肿瘤侵润肉瘤
分类号：R738.1(运动系肿瘤)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 41-44 )
英文信息