骨肉瘤凋亡与耐药相关机制的研究进展
陈楷1
吕书军1
付东2
李国东2
蔡郑东3
1.南通大学附属海安县人民医院骨科, 江苏,2266002.同济大学附属上海第十 人民医院骨科, 上海,2000723.上海市第一人民医院骨科
摘要：Osteosarcoma is one of the most common malignant bone tumors. The cure rate of the traditional surgery is low and amputation, lung metastases and death often occur. Currently, the neoadjuvant therapy with the combination of chemotherapy and surgery is an important method in the treatment of osteosarcoma. Abnormal apoptosis and drug resistance of osteosarcoma are major causes of clinical treatment failure. The changes of various genes and protein pathways are noticed with the appearance of abnormal apoptosis and drug resistance of osteosarcoma. The most common apoptosis-related genes include B-cell lymphoma-2 ( Bcl-2 ) family ( Bcl-2, Bax et al. ), Fas / Fas Ligand ( FasL ) family, Caspases, p53 family and so on. The drug resistance genes / proteins cover multidrug resistance-1 ( MDR-1 ), P-glycoprotein ( P-gp ), multi-drug resistance protein ( MRP ), high mobility group box 1 protein ( HMGB1 ) and others. The research on these molecular pathways may help to reveal the mechanism of abnormal apoptosis and drug resistance of osteosarcoma. And we could understand the mechanism of malignant biological behaviors of osteosarcoma better. Through further studies, new targets of gene therapy for osteosarcoma may be found in the related pathways, which could bring revolutionary progress in reversing drug resistance, regulating abnormal apoptosis and improving the clinical effects in the treatment of osteosarcoma.
关键词：骨肉瘤细胞凋亡抗药性肿瘤药理作用分子作用机制
分类号：R738.1(运动系肿瘤)
资助基金：国家自然科学基金(81202116)高等学校博士学科点专项科研基金(20100072120056)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 45-49 )
英文信息