蛋白聚糖异常代谢在关节炎损伤机制中的作用
杨文芳1
周惠琼2
1.卫生部中日友好医院风湿免疫科, 北京,1000292.解放军总医院第一附属医院内分泌 风湿科, 北京,100048
摘要：Joint injury is one of the main pathological characteristics of arthritis, which may lead to chronic and persistent joint swelling, pain, stiffness and dysfunction. Covering the joint surface, the articular cartilage has lubrication action among the bones and can resist the pressure caused by joint activities. Proteoglycan is one of the most important extracellular matrix components of the articular cartilage. Degradation of the extracellular matrix of the cartilage acts as a mark of joint injuries, and abnormal degradation of proteoglycans is an early signal of joint injuries. There are 2 main proteolytic enzymes that can degrade proteoglycans, which are matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs. Both enzymes can act on different parts of the proteoglycans, and generate different metabolic fragments which are monitored for joint destruction. In recent years, there are some new discoveries about the relationship of proteoglycans and joint injuries. In this paper, these studies are summarized, and the role of abnormal metabolism of proteoglycans in the injury mechanism of arthritis is explored in terms of the metabolic characteristics and impact factors of proteoglycans.
关键词：蛋白聚糖类代谢关节炎骨关节炎类风湿
分类号：R684.3(骨科学（运动系疾病、矫形外科学）)
资助基金：首都临床特色应用研究项目(Z121107001012019)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 49-53 )
英文信息