肉瘤中 FGFR 信号通路研究进展
周文雅
王国文
杨蕴
杨吉龙
1.300060,天津医科大学附属肿瘤医院骨与软组织肿瘤科 国家肿瘤临床研究中心 天津市肿瘤防治重点 实验室2.300060,天津医科大学附属肿瘤医院骨与软组织肿瘤科 国家肿瘤临床研究中心 天津市肿瘤防治重点 实验室3.300060,天津医科大学附属肿瘤医院骨与软组织肿瘤科 国家肿瘤临床研究中心 天津市肿瘤防治重点 实验室4.300060,天津医科大学附属肿瘤医院骨与软组织肿瘤科 国家肿瘤临床研究中心 天津市肿瘤防治重点 实验室
摘要：Sarcomas are derived from mesenchymal tissues, with poor outcomes of traditional treatment such as surgery, chemotherapy, and radiotherapy. Hence, new treatment methods such like target therapy in human cancer are very necessary. Fibroblast growth factor receptor ( FGFR ) signaling pathway plays a ubiquitous role in a variety of biological processes including regulating normal cell growth, proliferation, differentiation, and angiogenesis, but has also associated with a variety of dysplasia syndromes and cancers. The therapies and related drugs which target at FGFR signaling pathway have made great progress in the ifeld of tumors. An overview of the role of FGF / FGFR pathway signal and their inhibitors in sarcoma which might be new targets for the treatment of sarcomas according to the recent research will be presented.
关键词：肉瘤成纤维细胞生长因子成纤维细胞生长因子受体信号传导分子靶向治疗
分类号：R738(运动系肿瘤)
资助基金：国家自然科学基金(81372872)国家自然科学基金(81402215)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 720-724 )
英文信息