软骨组织工程种子细胞获取培养及鉴定研究进展
吕顺
周军杰
谢晓涛
陈贤奇
高文武
刘铖
张磊
1.200062,上海中医药大学附属普陀医院骨科2.200062,上海中医药大学附属普陀医院骨科3.200062,上海中医药大学附属普陀医院骨科4.200062,上海中医药大学附属普陀医院骨科5.200062,上海中医药大学附属普陀医院骨科6.200062,上海中医药大学附属普陀医院骨科7.200062,上海中医药大学附属普陀医院骨科
摘要：Objective To review the sources, cultivation and identiifcation of seed cells in cartilage tissue engineering.Methods Related basic research literature on obtaining seed cells in cartilage tissue engineering was reviewed and analyzed, while repeated research was removed.Results Chondrocytes could be induced and differentiated from animal carticular chodrocytes, mesenchymal stem cells ( MSCs ), induced pluripotent stem cells ( iPSCs ) and cartilage stem mesenchymal stem cells, which were proved to have typical chondrocyte characteristic and good biological characteristics.Conclusions These discoveries are lack of in-depth understanding on the exact mechanism that inducing factors induce differentiation of seed cells into chondrocytes. It remains to be articulated how the mechanism operates on inducing differentiation between cells and how to culture regenerated cartilage with characteristic morphology through 3-D printing and cartilage tissue engineering integration. Exploration of the underlying mechanisms will facilitate scientiifc progress for the clinical treatment of osteoarthritis and other related diseases.
关键词：组织工程间质干细胞骨生成胶原II型种子细胞
分类号：Q813(细胞工程)
资助基金：国家中医药管理局中医药重点学科建设项目( NO.2013QK20)上海中医药大学研究生“创新能力培养”专项科研项目(2015YCX14)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 864-867 )
英文信息