组织工程修复肩袖损伤促进腱骨愈合的研究进展
赵晨1
王蕾2
1.200025 上海交通大学医学院附属瑞金医院骨科; 上海市伤骨科研究所2.200025,上海交通大学医学院附属瑞金医院骨科
摘要：Rotator cuff injury, considered as a resource of pain, disability and dyssomnia to serious decline in the quality of life, is a common disorder of the shoulder joint. Basic principles of rotator cuff repair aim at achieving high initial ifxation strength, maintaining mechanical stability and restoring the anatomic healing of the cuff tendon. After the routine surgical procedure for rotator cuff repair, the biology and histology of the normal enthesis are not restored. Tendon-to-bone healing occurs with a ifbrovascular scar tissue interface that is mechanically inferior to the native insertion site, which may lead to high re-rupture rate. For these reasons, new approaches are required to improve structural healing. Tissue engineering strategies have been suggested to improve the biological environment around the bone-tendon interface and to promote regeneration of the native insertion site. Although experimental applications of growth factors and scaffolds on animal models demonstrate promising results, techniques which can be used in human rotator cuff repair are still very limited. Tissue engineering to improve tendon-to-bone healing has bright future and requires more research before its clinical applications. This review will outline therapies of growth factors, scaffolds and stem cells in tendon healing and rotator cuff repair.
关键词：组织工程干细胞胞间信号肽类和蛋白质类肩关节腱损伤创伤和损伤
分类号：R318(医用一般科学)R684(骨科学（运动系疾病、矫形外科学）)
资助基金：上海市卫生计生委项目(201440021)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 868-872 )
英文信息