三维打印技术在骨组织工程中的应用及进展
周怡
夏阳
章非敏
1.南京医科大学口腔疾病研究江苏省重点实验室, 江苏,2100292.南京医科大学口腔疾病研究江苏省重点实验室, 江苏,2100293.南京医科大学口腔疾病研究江苏省重点实验室, 江苏,210029
摘要：Bone tissue engineering includes 3 basic factors: cells, scaffolds and cytokines. The fast developments of bone tissue engineering provide new approaches for better restoration and reconstuction. Among them, new methods to fabricate optimal personalized scaffolds by three-dimensional ( 3 D ) bioprinting technique draw much attention. 3 D bioprinting is a branch of 3 D printing in biomedicine. It builds up a 3 D structure by printing with biomaterials and / or cells ( cytokines ). As a novel technique in tissue engineering, 3 D bioprinting performs better than traditional techniques. It can fabricate personalized scaffolds with high porosity and proper pore size easily and rapidly, and the scaffolds can meet the requirement of biocompatibility and mechanical strength in tissue engineering. Moreover, cells or cytokines can be deposited into biomaterials during printing, which can make the scaffolds both osteoinductive and osteoconductive. Although 3 D bioprinting has already been applied, it is still at a preliminary stage and improvement is still in need. It is important to search for the suitable approach for the deposition of cells and cytokines, to explore the way to maintain the bioactivity, and to develop new biomaterials for 3 D biopringting. With the development of medical imaging, digital medicine and new biomaterials, 3 D bioprinting will be used more and more in bone tissue engineering.
关键词：组织工程生物相容性材料细胞因子类计算机辅助设计三维打印
分类号：R318(医用一般科学)
资助基金：国家自然科学基金(81400486)江苏省自然科学基金(BK20140911)中国博士后科学基金(1402044B)中国博士后科学基金(2015M571647)江苏高校优势学科建设工程项目(2014-37)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 872-876 )
英文信息