肋骨肿瘤致低磷性骨软化症一例报告
沈荣凯
方凯彬
张文明
林建华
1.350000,福建医科大学附属第一医院骨肿瘤与关节外科2.350000,福建医科大学附属第一医院骨肿瘤与关节外科3.350000,福建医科大学附属第一医院骨肿瘤与关节外科4.350000,福建医科大学附属第一医院骨肿瘤与关节外科
摘要：Tumor-induced osteomalacia ( TIO ) is a rare paraneoplastic syndrome resulting in renal phosphate wasting and decreased bone mineralization. Nonspeciifc symptoms including fatigue, bone pain, and musculoskeletal weakness make the diagnosis elusive and often lead to a delay in treatment. The prognosis of TIO is excellent following complete resection of the neoplasm, which leads to a rapid and complete reversal of all symptoms. If the tumor cannot be detected, treatment relies on supplementation with phosphate and active vitamin D compounds. We report a case of rib tumors presenting a long history of progressively worsening muscular pain and weakness, and limitation in the motion and function of multiple joints. To our knowledge, this is the ifrst case of rib tumor-related hypophosphatemic osteomalacia reported in the literature. Our aim is to make physicians realize that any patient with unexplained muscular weakness and pain must undergo workup for TIO, including serum phosphate measurement, as this is a rare but potentially curable disease.
关键词：骨软化症低磷血症肋骨肿瘤
分类号：R738.1(运动系肿瘤)
资助基金：福建医科大学临床医学重点学科资助项目(XK201106)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 907-909 )
英文信息