内质网应激和JNK信号通路在骨关节炎中的相关作用
李晓东1
姚晓2
王晓庆1
1.上海市骨科内植物重点实验室, 上海交通大学医学院附属第九人民医院骨科,2000112.上海恒健生物技术有限公司, 上海张江普汇转化医学研究院,200433
摘要：Osteoarthritis ( OA ), the most common type of osteoarthrosis, is a leading cause of disability in the elderly. Although a number of studies have shown that predispositions include aging, obesity, joint injury, congenital anomalies, joint deformities etc., but the exact etiology and pathogenesis are not fully understood and there is currently no effective disease-modifying treatment. Under the comprehensive effects of systemic and local factors, changes in the structure and metabolism of the articular cartilage occur progressively, culminating in articular cartilage softening, ulceration, local stripping and joint edge of the bone and cartilage excrescence formation etc. The initiation and progression of OA subtypes is a complex process that at the molecular level probably involves many cell types and signaling pathways. Increasing evidence implicates that the endoplasmic reticulum stress ( ERS ) and c-Jun N-terminal kinase ( JNK ) signaling pathway are probably involved to some degree in OA etiology and pathogenesis. Endoplasmic reticulum is an important organelle in cells, which is easy to cause the endoplasmic reticulum stress, leading to the endoplasmic reticulum related death, while the apoptosis of chondrocytes is one of the important pathological manifestations of osteoarthritis. C-Jun N-terminal kinase signal pathway was discovered in the past 20 years which was related to the cell differentiation, apoptosis, stress response and a variety of diseases occurrence and development. This review summarized the current knowledge of ERS as well as the JNK signaling pathway and their interactions regulating OA progression.
关键词：骨关节炎信号传导内质网应激细胞凋亡综述
分类号：R684(骨科学（运动系疾病、矫形外科学）)
资助基金：国家自然科学基金(81272036)
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 520-524 )
英文信息