人工关节磨损颗粒对骨髓间充质干细胞影响的研究现状
王荣
周胜虎
李旭升
1.兰州军区兰州总医院全军骨科中心关节骨病外科, 甘肃,7300502.兰州军区兰州总医院全军骨科中心关节骨病外科, 甘肃,7300503.兰州军区兰州总医院全军骨科中心关节骨病外科, 甘肃,730050
摘要：To review the research status of the effects of joint prosthesis wear particles on bone marrow mesenchymal stem cells ( BMSCs ). Joint prosthetic replacement is an effective way to treat osteoarthrosis of advanced stage, which can get rid of arthral pain, eliminate the joint deformities and rebuild the function of activity to boost life quality. Aseptic loosening is the main reason of the failure of arthroplasty. Wear particle induced biological reaction in tissues surrounding the prosthesis is an important factor of osteolysis and aseptic loosening after the arthroplasty. Wear particles move into the bone marrow cavity through the implant-bone interface membrane pathways, and interact with BMSCs. Wear particles affect the bone regeneration and reconstruction around the prosthesis by influencing adhesion and migration, proliferation and osteogenic differentiation and expression of osteoprotegerin ( OPG ) and receptor activator for nuclear factor-κB ligand ( RANKL ) of BMSCs. Decoy oligodeoxynucleotides for NF-κB could enhance the activity and OPG expression of BMSCs. Diphosphate could inhibit the release of inlfammatory cytokines and promote the proliferation and osteogenic differentiation, playing a positive role in the prevention and treatment of aseptic loosening.
关键词：人工关节间充质干细胞综述磨损颗粒
分类号：R687.4(骨科学（运动系疾病、矫形外科学）)Q813(细胞工程)
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 775-778 )
英文信息