骨形态发生蛋白2在腰椎融合术中应用的效果与并发症
禹名卉1
赵彦涛2
衷鸿宾2
王福利2
韩丽伟2
张改巾2
钱隆2
1.锦州医科大学研究生学院, 辽宁,1210002.解放军总医院第一附属医院、北京市骨科植入医疗器械工程技术研究中心, 北京,100048
摘要：Objective To summarize the effects and complications of bone morphogenetic protein-2 ( BMP-2 ) used in lumbar fusion surgery.Methods CNKI, Embase and Pubmed databases were searched for articles on BMP-2 application by a computer with key words "BMP-2", "lumbar fusion", "complications" and "bone healing". Eligible articles published during the recent 10 years were enrolled.Results Bone morphogenetic protein could promote the rate of bone fusion and shorten integration time, and there were potential applications in the field to promote bone fusion, but studies had shown that using BMP-2 in lumbar fusion process can also lead to adverse results and complications.Conclusions Although BMP-2 can substitute for autologous bone and allograft transplantation, reduce the damage and immune rejection in other parts of the body, but the surgical method and its quantity of application and postoperative adverse outcomes require further studies .
关键词：腰椎脊柱融合术手术中并发症骨折愈合骨形态发生蛋白2
分类号：R681.5(骨科学（运动系疾病、矫形外科学）)R687.3(骨科学（运动系疾病、矫形外科学）)
资助基金：国家自然科学基金(81201380)军事医学项目(13CXZ028,AWS14C007)北京市自然科学基金(7152144)北京市科技新星计划(Z1511000003150134)临床部项目(2014ZD001)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 228-231 )
英文信息